Investigators searching for missing Arizona woman Nancy Guthrie may need to return to her home for a new round of DNA collection, according to leading forensic experts.
The case — involving the 84-year-old mother of Savannah Guthrie — remains unsolved more than two months after her disappearance, with no suspects publicly identified.
DNA evidence still key to solving case
Authorities previously confirmed that DNA recovered from Guthrie’s Tucson home was “mixed,” meaning it contained genetic material from multiple individuals, complicating efforts to identify a suspect.
Now, genetic genealogy expert CeCe Moore says new forensic technology could help isolate usable DNA and potentially lead to a breakthrough.
Experts believe advances in DNA analysis — including tools designed to separate complex mixtures — may allow investigators to extract a clear genetic profile even from previously unusable samples.
Moore suggested that returning to the home to re-collect evidence from high-contact areas could increase the chances of finding trace DNA left behind.
Case remains unsolved months later
Nancy Guthrie was last seen on January 31, 2026, before being reported missing the following day under suspicious circumstances. Authorities believe she was abducted from her home in Tucson, Arizona. (Wikipedia)
Surveillance footage captured a masked individual outside her residence around the time of her disappearance, while investigators later confirmed the presence of blood evidence at the scene.
Despite tens of thousands of tips and an extensive investigation involving federal and local agencies, no arrests have been made.
New technology offers hope
Forensic specialists say emerging tools — including advanced DNA sequencing and software designed to separate mixed genetic samples — could play a critical role in solving the case.
Even trace evidence, such as DNA left on everyday surfaces like doorknobs, could be enough to identify a suspect if properly analyzed, experts say.
Moore has emphasized that in cases like this, it is highly likely that the perpetrator left behind some form of DNA, even if it has not yet been successfully isolated.
Investigation continues
Officials have not confirmed whether additional searches of the home will take place, but experts say revisiting the scene could provide another opportunity to collect critical evidence.
The case remains one of the most closely watched missing-person investigations in the United States, with authorities continuing to pursue leads and urging the public to come forward with information.